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Target intelligence / Profile preview
Nicotinic Acetylcholine Receptor Alpha-7 (α7 nAChR)
- Target
- α7 nAChR
- Molecular classification
- Ligand-gated ion channel, Cys-loop receptor, Receptor
01
Overview
The nicotinic acetylcholine receptor alpha-7 subunit (α7 nAChR) is a ligand-gated ion channel and a member of the Cys-loop receptor superfamily. It forms homopentameric channels highly permeable to calcium ions (Ca²⁺). It mediates fast synaptic transmission, modulates neurotransmitter release, and plays a role in inflammation. It is implicated in diseases such as Alzheimer's, Schizophrenia and cancer, making it a target for drug development.
- Other names
- alpha-7 nicotinic acetylcholine receptorCHRNA7
02
Mechanism of action
Upon binding acetylcholine or selective agonists, the α7 nAChR channel opens, allowing Ca²⁺ influx. This triggers downstream signaling pathways affecting neurotransmitter release or cellular responses. The channel quickly desensitizes even if ligand remains bound.
03
Biological functions
Synaptic transmissionNeurotransmitter release modulationSynaptic plasticityCalcium ion influxImmune response regulationCognitive functionNeurogenesis
04
Disease associations
Alzheimer’s diseaseSchizophreniaInflammationSepsisStrokeMyocardial infarctionAtherosclerosisCancer
05
Safety considerations
Activation or inhibition can have both beneficial or detrimental effects depending on cell type and context.Rapid desensitization of the receptor presents a therapeutic challenge.
06
Interacting drugs
GTS-21 (DMXB-A)
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