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Nicotinic Acetylcholine Receptor Alpha3 Beta4 Subtype (nAChR α3β4)
- Target
- nAChR α3β4
- Molecular classification
- Ligand-gated ion channel, Neuronal nicotinic acetylcholine receptor, Cys-loop receptor superfamily
01
Overview
The nicotinic acetylcholine receptor alpha3 beta4 subtype (nAChR α3β4) is a pentameric ligand-gated ion channel composed of α3 and β4 subunits. It is primarily found in autonomic ganglia and the adrenal medulla, mediating fast synaptic transmission. It is a target for developing treatments against nicotine addiction and potentially other substance use disorders.
- Other names
- Ganglion-type nicotinic receptor
02
Mechanism of action
Ion channel agonist/antagonist; modulation of synaptic transmission
03
Biological functions
Fast synaptic transmissionPost-synaptic excitationPre-synaptic excitation
04
Disease associations
Nicotine addictionSubstance use disorders
05
Interacting drugs
Acetylcholine
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