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Target intelligence / Profile preview
Nicotinic Acetylcholine Receptor Alpha3Beta2 Subtype
- Molecular classification
- Ligand-gated ion channel, Cys-loop superfamily, Receptor
01
Overview
The nicotinic acetylcholine receptor (nAChR) alpha3beta2 subtype is a neuronal nAChR that responds to acetylcholine and nicotine. It is a pentameric ligand-gated ion channel found in the central and peripheral nervous systems. Upon ligand binding, it allows cation influx, mediating fast synaptic transmission. It plays roles in neurotransmitter release, synaptic plasticity, pain processing, and autonomic ganglionic transmission. Dysfunction is implicated in pain, addiction, and neurodegenerative diseases, making it a target for drug development.
02
Mechanism of action
Agonist-induced cation channel opening, leading to membrane depolarization
03
Biological functions
Fast excitatory neurotransmissionNeurotransmitter release modulationSynaptic plasticityAutonomic ganglionic transmission
04
Disease associations
Pain syndromesAddictionNeurodegenerative diseases
05
Safety considerations
Potential for off-target effects on other nAChR subtypesRisk of side effects due to modulation of cholinergic signaling
06
Interacting drugs
Acetylcholine
2 more in the full profile.
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