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Target intelligence / Profile preview
Nicotinic acetylcholine receptor alpha4 beta2 subtype (α4β2 nAChR)
- Target
- α4β2 nAChR
- Molecular classification
- Ligand-gated ion channel, Receptor
01
Overview
The nicotinic acetylcholine receptor alpha4 beta2 subtype (α4β2 nAChR) is a ligand-gated ion channel and a major neuronal nicotinic acetylcholine receptor in the brain. It is composed of alpha-4 (CHRNA4 gene) and beta-2 (CHRNB2 gene) subunits. This receptor plays a critical role in synaptic transmission, cognitive function, reward pathways, and is the primary biological target mediating nicotine's addictive properties.
- Other names
- Alpha4 beta2 nicotinic acetylcholine receptorα4β2 receptor
02
Mechanism of action
Ligand-gated ion channel activation/inhibition; positive/negative allosteric modulation
03
Biological functions
Synaptic transmissionNeuronal signalingModulation of growth hormone secretion
04
Disease associations
Nicotine addictionCognitive disordersCardiovascular disease (aneurysm/dissection, blood pressure dysregulation)Obesity
05
Interacting drugs
Acetylcholine
2 more in the full profile.
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