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Target intelligence / Profile preview
Nicotinic Acetylcholine Receptor Alpha7 Subtype (nAChR α7)
- Target
- nAChR α7
- Molecular classification
- Cys-loop ligand-gated ion channel, Receptor, Ion channel
01
Overview
The nicotinic acetylcholine receptor alpha7 subtype (nAChR α7) is a homopentameric ligand-gated ion channel highly permeable to calcium ions. It plays critical roles in both the central nervous system and peripheral tissues, mediating fast synaptic transmission and modulating various physiological processes including cognition, inflammation, and neuroprotection. It is a therapeutic target for Alzheimer's disease, schizophrenia, cognitive disorders and inflammatory conditions.
- Other names
- alpha7 nAChRCHRNA7 receptor
02
Mechanism of action
Ligand-gated ion channel activation/inhibition; allosteric modulation
03
Biological functions
NeurotransmissionCalcium signalingSynaptic plasticityNeuroprotectionImmune modulation
04
Disease associations
Alzheimer's diseaseSchizophreniaCognitive disordersInflammatory diseasesSepsis
05
Safety considerations
Potential for off-target effects due to promiscuity of agonistsRapid desensitization may limit therapeutic efficacyComplex interplay with other neurotransmitter systems
06
Interacting drugs
GTS-21 (DMXB-A)
6 more in the full profile.
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