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Target intelligence / Profile preview
Nicotinic Acetylcholine Receptor Alpha7 Subunit (α7 nAChR)
- Target
- α7 nAChR
- Molecular classification
- Receptor, Ion channel, Ligand-gated ion channel, Cys-loop receptor
01
Overview
The nicotinic acetylcholine receptor alpha7 subunit (α7 nAChR) is a ligand-gated ion channel that forms functional receptors as homopentamers. It is highly permeable to calcium ions (Ca²⁺), with rapid desensitization kinetics. Activation leads to increased Ca²⁺ influx, mediating pre- and post-synaptic excitation and modulating inflammation. It is implicated in various diseases, including Alzheimer's, schizophrenia, inflammatory conditions, and cancer, making it a target for drug development.
- Other names
- CHRNA7Cholinergic receptor nicotinic alpha 7 subunit
02
Mechanism of action
Agonist or antagonist of nicotinic acetylcholine receptor alpha7 subunit
03
Biological functions
Fast synaptic transmission/modulationAnti-inflammatory signalingCalcium ion influxNeuronal signalingMemory formationAttention regulationNeurogenesisAngiogenesisCell proliferationCell migrationCell survivalApoptosis balance
04
Disease associations
Cognitive impairmentNeurodegenerative diseases (Alzheimer’s)SchizophreniaInflammatory diseases/sepsisCardiovascular disease progressionAtherosclerosisCancer cell proliferation/metastasis
05
Interacting drugs
RG3487
7 more in the full profile.
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