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Nicotinic Acetylcholine Receptor Alpha7 Subunit Containing (α7 nAChR)
- Target
- α7 nAChR
- Molecular classification
- Ligand-gated ion channel, Nicotinic acetylcholine receptor
01
Overview
The nicotinic acetylcholine receptor alpha7 subunit containing (α7 nAChR) is a homopentameric ligand-gated ion channel primarily permeable to calcium ions. It is highly expressed in the central nervous system and peripheral tissues, playing critical roles in synaptic transmission, plasticity, and immune regulation. α7 nAChRs are implicated in various diseases, including cognitive disorders, inflammation, and cancer, making them a target for therapeutic intervention.
- Other names
- Alpha7 nicotinic acetylcholine receptorCholinergic receptor, nicotinic, alpha 7 subunit
02
Mechanism of action
Activation of α7 nAChRs leads to calcium influx and downstream signaling pathways including JAK2–STAT3, AMPK–mTOR, and calcium-induced calcium release.
03
Biological functions
Synaptic transmissionSynaptic plasticityCalcium signalingNeurotransmitter release modulationImmune regulationAnti-inflammatory signaling
04
Disease associations
Alzheimer's diseaseSchizophreniaCognitive disordersSepsisRheumatoid arthritisInflammatory bowel diseaseStrokeCancerAtherosclerosis
05
Interacting drugs
Acetylcholine
12 more in the full profile.
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