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Nicotinic Acetylcholine Receptor Subunit Alpha-7
- Molecular classification
- Ligand-gated ion channel, Receptor
01
Overview
The nicotinic acetylcholine receptor subunit alpha-7 (α7 nAChR) is a homopentameric ligand-gated ion channel formed by five identical α7 subunits. It is highly permeable to calcium ions and plays critical roles in neuronal and non-neuronal signaling. It is implicated in cognitive disorders such as Alzheimer's disease and schizophrenia, and its modulation is considered promising for treatment strategies targeting these conditions. Other roles include neuroprotection, inflammation regulation, pain modulation, and cancer progression.
- Other names
- α7 nAChRCHRNA7
02
Mechanism of action
Agonist, antagonist, or positive allosteric modulator of α7 nAChR
03
Biological functions
NeurotransmissionSynaptic plasticityCalcium signalingAnti-apoptotic signalingAnti-inflammatory signalingAutophagy inductionModulation of glutamatergic/GABAergic transmission
04
Disease associations
Alzheimer's diseaseSchizophreniaJuvenile myoclonic epilepsyInflammationCancer
05
Safety considerations
Rapid desensitizationPotential for off-target effects due to widespread expressionRisk associated with modulating calcium signaling
06
Interacting drugs
Acetylcholine (ACh)
6 more in the full profile.
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