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Target intelligence / Profile preview
Nicotinic Acetylcholine Receptor Subunit Beta-2 (CHRNB2)
- Target
- CHRNB2
- Molecular classification
- Ligand-gated ion channel superfamily, Cys-loop family, Receptor
01
Overview
The nicotinic acetylcholine receptor subunit beta-2 (CHRNB2) is a protein that forms part of the neuronal nicotinic acetylcholine receptors (nAChRs), ligand-gated ion channels found throughout the central and peripheral nervous systems. These receptors play critical roles in synaptic transmission, modulation of neurotransmitter release, cognitive processes, learning, memory formation, attention regulation, and reward pathways. Mutations in CHRNB2 have been linked to autosomal dominant nocturnal frontal lobe epilepsy, and variants in this gene may also influence susceptibility to nicotine dependence.
- Other names
- Neuronal acetylcholine receptor subunit beta-2
02
Mechanism of action
Agonist binding leads to opening of the ion channel pore, allowing cation influx (Na+, K+, Ca2+).
03
Biological functions
Synaptic transmissionModulation of neurotransmitter releaseCognitive processesLearningMemory formationAttention regulationReward pathwaysIon channel activity
04
Disease associations
Autosomal dominant nocturnal frontal lobe epilepsyNicotine dependenceDepression
05
Safety considerations
Potential for seizures (in the context of epilepsy-linked mutations)Addiction liability (due to involvement in nicotine dependence)
06
Interacting drugs
Acetylcholine
1 more in the full profile.
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