Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Nidovirus RdRP-associated nucleotidyltransferase (NiRAN)
- Target
- NiRAN
- Molecular classification
- Enzyme, Nucleotidyltransferase, Polymerase Domain
01
Overview
The Nidovirus RdRP-associated nucleotidyltransferase (NiRAN) is a unique enzymatic module universally present at the N terminus of all known nidoviral polymerases. Its essential role in nucleotide transfer reactions required for efficient genome replication, transcription initiation, and possibly mRNA capping makes it both fundamental to virus biology and an attractive target for broad-spectrum antivirals targeting diseases such as COVID-19.
- Other names
- NiRAN Domain
02
Mechanism of action
Inhibition of nucleotidyltransferase activity, disruption of RNA replication and transcription
03
Biological functions
RNA replicationTranscription initiationmRNA cappingProtein PrimingNucleotide transfer
04
Disease associations
Infection
05
Safety considerations
Potential for off-target effects on cellular nucleotidyltransferasesDevelopment of resistance
Beyond the preview
Go deeper on Nidovirus RdRP-associated nucleotidyltransferase (NiRAN).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Nidovirus RdRP-associated nucleotidyltransferase (NiRAN).