Target intelligence / Profile preview

Nidovirus RdRP-associated nucleotidyltransferase domain (NiRAN)

Target: NiRAN
Molecular classification: Enzyme, Viral protein, Nucleotidyltransferase

Overview

The NiRAN domain is a conserved N-terminal domain found in the RNA-dependent RNA polymerase (RdRp) of all nidoviruses. It possesses nucleotidyltransferase and kinase-like activities, playing a crucial role in viral RNA synthesis, mRNA capping, and replication priming. Its conservation and essential function make it an attractive antiviral drug target.

Mechanism of action

Inhibition of NiRAN kinase-like activity

Biological functions

Viral RNA synthesismRNA cappingRNA replication primingNucleotidyl transfer

Disease associations

Infection

Safety considerations

Potential for off-target effectsDevelopment of resistance

Interacting drugs

Sorafenib

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