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Target intelligence / Profile preview
Niemann-Pick C1-Like 1 Transporter (NPC1L1)
- Target
- NPC1L1
- Molecular classification
- Transporter, Multi-pass transmembrane protein
01
Overview
Niemann-Pick C1-Like 1 (NPC1L1) is a multi-pass transmembrane protein that mediates the uptake of free cholesterol into cells, primarily in the intestine. It plays a crucial role in cholesterol absorption and whole-body cholesterol homeostasis. It is the target of ezetimibe, a drug used to lower LDL-cholesterol levels.
02
Mechanism of action
Inhibition of cholesterol uptake by blocking the sterol transport activity of NPC1L1
03
Biological functions
Cholesterol absorptionPhytosterol absorptionRegulation of cholesterol homeostasis
04
Disease associations
HypercholesterolemiaAtherosclerosis
05
Interacting drugs
Ezetimibe
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