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Target intelligence / Profile preview
NIMA related kinase 7 (None)
- Target
- None
- Molecular classification
- Enzyme, Serine/threonine kinase, NIMA-related kinase family
01
Overview
NIMA related kinase 7 (NEK7) is a serine/threonine protein kinase and a member of the NIMA (never in mitosis gene a)-related kinase family. It plays essential roles in mitotic cell cycle progression, microtubule nucleation, mitotic spindle formation, cytokinesis, and NLRP3 inflammasome activation. It's involved in various diseases including Alzheimer’s disease, coronary atherosclerosis, diabetes mellitus type II, Muckle-Wells syndrome, and familial cold autoinflammatory syndrome. NEK7 represents an attractive target for therapeutic intervention against cancers characterized by abnormal proliferation or inflammatory diseases driven by aberrant inflammasome activation.
- Other names
- Serine/threonine-protein kinase Nek7NIMA-related kinase 7
02
Mechanism of action
Small molecule inhibitors targeting catalytic site or regulatory interactions within cell division or inflammasome pathways.
03
Biological functions
Cell cycle regulationMitotic spindle formationCentrosomal microtubule nucleationCytokinesisNLRP3 inflammasome activationInnate immune response
04
Disease associations
Alzheimer’s diseaseCoronary AtherosclerosisDiabetes Mellitus Type IIMuckle-Wells SyndromeFamilial Cold Autoinflammatory SyndromeInflammationCancer
05
Safety considerations
Potential for disrupting normal cell division processesPotential for affecting immune responses
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