Ninein (NIN)

Ninein is a large coiled-coil centrosomal protein encoded by the NIN gene on human chromosome 14. It acts as an anchor for microtubule minus-ends at the subdistal appendages of mother centrioles and the pericentriolar material (PCM), regulating microtubule nucleation and organization. Ninein interacts with γ-tubulin and plays a crucial role in the positioning, stability, and recruitment of microtubule-organizing complexes. In neural and epithelial cells, Ninein supports cell division polarity and stem cell self-renewal by directing asymmetric inheritance of centrosomes. Mutations in NIN cause Seckel syndrome, a congenital disorder characterized by primordial dwarfism and neurodevelopmental deficits. Multiple alternatively spliced isoforms exist and may have tissue-specific roles. Ninein is not considered a direct pharmacological target, but its disruption is implicated in genetic and developmental diseases.

Other names

NineinNINKIAA1565hNineinSeckel syndrome protein (SCKL7)Glycogen synthase kinase 3 beta-interacting proteinGSK3B-interacting proteinNinein centrosomal protein