NIPA-like domain containing 3 (NIPAL3)

NIPA-like domain containing 3 (NIPAL3) is a protein-coding gene that encodes a membrane transporter predicted to enable magnesium ion transmembrane transporter activity[1][2][3][4]. NIPAL3 is part of the NIPA family, proteins known for encoding receptors or transporters implicated in neurodevelopmental processes and is expressed in various tissues including the nervous system[2]. Disruption of NIPAL3 causes neurological impairments and immune disturbances in animal models, manifesting as abnormal behavior, altered immunoglobulin levels, reduced NK cell counts, and impaired lung function[2]. The human gene lies in a genomic region associated with atopic diseases and has been linked to combined oxidative phosphorylation deficiency and immunodeficiency syndromes[1][2]. Despite its physiological importance, NIPAL3 is not currently pursued as a therapeutic drug target, nor are there any known inhibitors, modulators, or drugs in clinical use or development directed at this specific transporter[1][2].

Other names

NPAL3DJ462O23.2SLC57A5NIPA-like protein 3

Not established, as no drugs are documented to interact directly with this molecule[1][2].