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Target intelligence / Profile preview
Nipah Virus Antigen (NiV Antigen)
- Target
- NiV Antigen
- Molecular classification
- Viral protein, Glycoprotein, Structural protein
01
Overview
Nipah virus antigens are viral proteins, most notably the surface glycoproteins G (attachment protein) and F (fusion protein), and the nucleocapsid protein N. These antigens are key targets for diagnostic assays, vaccine development, and therapeutic antibody design. The G glycoprotein mediates attachment to host cell receptors (ephrin-B2 and ephrin-B3), while the F glycoprotein facilitates membrane fusion. The N protein is an internal structural protein used in diagnostics due to its high abundance. These antigens elicit immune responses, particularly neutralizing antibodies against G and F, which are critical for protection against Nipah virus infection.
- Other names
- NiV AntigenNipah virus proteinsNipah virus surface glycoproteinsNiV glycoproteinsNipah virus structural proteins
02
Mechanism of action
Neutralization of viral entry, inhibition of viral replication
03
Biological functions
Viral attachmentMembrane fusionImmune evasionReceptor bindingViral replicationEliciting immune response
04
Disease associations
Nipah virus infectionEncephalitisRespiratory illness
05
Safety considerations
Potential for antibody-dependent enhancement (ADE)Cross-reactivity with other henipavirusesEpitope variation leading to vaccine escape
06
Biomarkers
Antibody titers against G and F glycoproteinsViral load
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