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Target intelligence / Profile preview
Nipah virus attachment glycoprotein (NiV-G)
- Target
- NiV-G
- Molecular classification
- Viral glycoprotein, Attachment protein
01
Overview
The Nipah virus attachment glycoprotein (NiV-G) is a surface protein essential for viral entry into host cells. It mediates viral attachment by binding to ephrin-B2 and ephrin-B3 receptors, triggering conformational changes that activate the fusion glycoprotein (F) for membrane fusion. NiV-G is a major target for neutralizing antibodies and antiviral drug development due to its critical role in initiating infection.
- Other names
- NiV G proteinNipah virus G glycoproteinAttachment glycoprotein G
02
Mechanism of action
Disruption of G-ephrin interaction
03
Biological functions
Viral attachmentReceptor bindingMembrane fusion initiationViral entry
04
Disease associations
Nipah virus infectionEncephalitisRespiratory illness
05
Safety considerations
Sequence divergence at key epitope sitesConformational epitopes
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