Nipped-B homolog pseudogene

The "Nipped-B homolog pseudogene" (ENSG00000253233) is a DNA segment in the human genome resembling the Nipped-B homolog (NIPBL) gene but lacking the ability to produce a functional protein. Pseudogenes like this are formed through gene duplication or retrotransposition events, resulting in a sequence similar to the original gene but usually lacking regulatory elements and/or being disrupted by mutations such as premature stop codons or frameshifts[1][3]. As a pseudogene, ENSG00000253233 is not considered a therapeutic target and has no known direct biological function, disease association, or interactions with drugs[5][1]. Confusion can arise because the protein-coding NIPBL gene is an important target in human genetics, whereas its pseudogene variant is not functionally active[5][2][6]. This molecule serves primarily as a genomic reference and should not be used as a target in structured therapeutic or mechanistic databases.

Other names

ENSG00000253233NIPBL pseudogene