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Nischarin
- Molecular classification
- Scaffold protein, Sorting nexin-related protein
01
Overview
Nischarin is a cytosolic scaffolding protein that acts as a negative regulator of cell migration and cytoskeletal organization. It binds to integrin α5β1, inhibits Rac-mediated activation pathways, and modulates FAK phosphorylation, PAK/LIMK signaling, and Rac GTP loading. It is considered a functional candidate for the imidazoline-1 receptor (I1R) and exhibits tumor-suppressor-like characteristics. It interacts with integrins, IRS4, and Rac/Rab GTPases, influencing trafficking and signal modulation relevant to cancer biology and cellular motility control.
- Other names
- hIRASI-1IRASImidazoline receptor antisera-selected proteinImidazoline receptor 1I1RKIAA0975
02
Mechanism of action
Agonist for imidazoline-1 receptor (I1R) signaling (for Tizanidine, Agmatine, Moxonidine); inhibition of Nischarin (Tepotinib - mechanism unclear, direct action on Nischarin not established)
03
Biological functions
Regulation of actin cytoskeleton organizationNegative regulation of cell migrationInhibition of Rac-mediated activation pathwaysModulation of FAK phosphorylationModulation of PAK/LIMK signalingRegulation of integrin traffickingTumor suppression
04
Disease associations
Cancer
05
Interacting drugs
Tizanidine
3 more in the full profile.
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