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Nitric Oxide Donor (None)
- Target
- None
- Molecular classification
- Organic nitrate, Organic nitrite, Sydnonimine, Vasodilator
01
Overview
Nitric oxide donors are pharmacologically active substances that release nitric oxide (NO), a critical signaling molecule involved in numerous physiological and pathophysiological processes, especially within the cardiovascular system. These compounds serve as exogenous sources of NO, promoting vasodilation, inhibiting platelet aggregation, and influencing cardiac function.
- Other names
- NO donorNitrateNitriteSydnonimine
02
Mechanism of action
Release of nitric oxide (NO) or related species that activate soluble guanylyl cyclase (sGC), increasing cyclic guanosine monophosphate (cGMP) levels, leading to activation of cGMP-dependent protein kinases and reduced intracellular calcium concentrations, resulting in vasodilation and inhibition of platelet aggregation.
03
Biological functions
Nitric oxide releaseVasodilationPlatelet aggregation inhibitionSmooth muscle relaxation
04
Disease associations
Ischemic heart diseaseAngina pectorisHypertensionHeart failureAtherosclerosisArterial thrombotic disordersStroke
05
Safety considerations
Tolerance developmentShort half-lifeSystemic side effects (hypotension, headache)Potential adverse hemodynamic consequences
06
Interacting drugs
Nitroglycerin
2 more in the full profile.
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