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Nitric Oxide-cGMP Pathway (None)

Target: None
Molecular classification: Signaling Pathway

Overview

The nitric oxide (NO)-cGMP pathway is a fundamental cellular signaling cascade involved in diverse physiological processes, including smooth muscle relaxation, neural communication, inhibition of platelet aggregation, and pain modulation. NO, produced by NOS, activates sGC, leading to cGMP production. cGMP then activates downstream effectors like PKG. Dysregulation is implicated in cardiovascular and neurological diseases, making it a target for therapeutic intervention.

Mechanism of action

Modulation of nitric oxide production, sGC activation, or cGMP degradation.

Biological functions

Vascular tone regulationNeural communicationPlatelet functionPain processingBladder controlSignal transduction

Disease associations

Cardiovascular disordersChronic pain conditionsHypertensionHeart failure

Safety considerations

Hypotension (due to vasodilation)Drug interactions (particularly with nitrates)

Interacting drugs

Sildenafil

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