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Nitric Oxide Donors (NO Donors)
- Target
- NO Donors
- Molecular classification
- Chemical Compound, Drug
01
Overview
Nitric oxide donors are pharmacologically active compounds that release nitric oxide either spontaneously or through metabolic processes. They are used to mimic or augment endogenous NO signaling, primarily in the cardiovascular system, leading to vasodilation, inhibition of platelet aggregation, and modulation of other cellular processes. Key issues include tolerance development and short half-lives.
- Other names
- NitratesNitritesS-nitrosothiolsDiazeniumdiolatesMetal-NO complexesOrganic nitrates
02
Mechanism of action
Nitric oxide donors release nitric oxide, which activates soluble guanylyl cyclase (sGC), increasing cGMP levels and leading to smooth muscle relaxation and vasodilation.
03
Biological functions
VasodilationInhibition of platelet aggregationModulation of angiogenesisRegulation of inflammationRegulation of apoptosisNitric oxide signaling
04
Disease associations
Angina pectorisHeart failureHypertensionThrombosisAtherosclerosis
05
Safety considerations
Short therapeutic half-lifeSystemic absorption leading to adverse hemodynamic effectsDevelopment of drug tolerance with chronic use
06
Interacting drugs
Nitroglycerin
5 more in the full profile.
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