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Nitric Oxide Signaling Pathway (NO Pathway)
- Target
- NO Pathway
- Molecular classification
- Signaling Pathway
01
Overview
The nitric oxide (NO) signaling pathway is a fundamental cellular communication system in which NO acts as a gaseous signaling molecule. NO plays critical roles in regulating vascular tone, neurotransmission, immune responses, and other physiological processes.
- Other names
- Nitric Oxide PathwayNO signaling cascadeNitric Oxide Synthase pathway
02
Mechanism of action
Drugs targeting this pathway primarily modulate NO production, sGC activity, or cGMP degradation. Nitroglycerin and nitrates act as NO donors. PDE5 inhibitors prolong cGMP action by preventing its degradation.
03
Biological functions
Vascular tone regulationNeurotransmissionImmune responseVasodilationNeuromodulationRegulation of gene expression
04
Disease associations
Cardiovascular diseasesNeurodegenerative disordersInflammatory conditionsErectile dysfunctionHypertension
05
Safety considerations
Excessive vasodilation leading to hypotensionPotential for drug interactions with other vasodilators
06
Interacting drugs
Nitroglycerin
2 more in the full profile.
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