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Nitric Oxide Synthase, Neuronal (nNOS)
- Target
- nNOS
- Molecular classification
- Enzyme, Oxidoreductase
01
Overview
Neuronal nitric oxide synthase (nNOS), also known as NOS I, is an enzyme responsible for the synthesis of nitric oxide (NO) in neurons. NO acts as a gaseous signaling molecule with diverse roles in the central and peripheral nervous systems. nNOS activity is calcium/calmodulin-dependent; it catalyzes the oxidation of L-arginine to produce NO and citrulline when activated by increased intracellular Ca²⁺ levels following NMDA receptor stimulation. Altered nNOS function has been implicated in various neurological disorders due to its role in synaptic signaling, neurodevelopmental processes, cardiovascular regulation, oxidative stress response in myocardium, heart failure prevention, basal blood flow maintenance, and autonomic cardiac control.
- Other names
- NOS INOS1
02
Mechanism of action
Inhibition of nitric oxide production by blocking the oxidation of L-arginine.
03
Biological functions
Synaptic plasticityNeurogenesisBlood pressure regulationSmooth muscle relaxationSignal transduction
04
Disease associations
Neurological disordersHypertensionNeurodegenerative diseaseCardiovascular disease
05
Safety considerations
Inhibition impairs learning/memoryDysregulation may contribute to hypertension or neurodegenerative diseases
06
Interacting drugs
N-propyl-L-arginine (NPA)
1 more in the full profile.
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