Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Nitric oxide synthase 1 (NOS1)
- Target
- NOS1
- Molecular classification
- Enzyme, Nitric oxide synthase
01
Overview
Nitric oxide synthase 1 (NOS1) catalyzes the production of nitric oxide (NO) from L-arginine and molecular oxygen. NO acts as a neurotransmitter, neuromodulator, and has roles in muscle tissue function and vascular regulation. Dysregulation is implicated in neurological disorders and cardiac dysfunctions.
- Other names
- Neuronal nitric oxide synthase (nNOS)Constitutive NOSEC 1.14.13.39IHPS1N-NOSNC-NOSNOS type IbNOSpeptidyl-cysteine S-nitrosylase NOS1[7]
02
Mechanism of action
Nitric oxide production from L-arginine and molecular oxygen.
03
Biological functions
Nitric oxide productionNeurotransmissionNeuromodulationRegulation of Ca²⁺ reuptakeAntimicrobial activityAntitumoral activity
04
Disease associations
StrokeNeurodegenerative diseaseCardiac dysfunction
05
Safety considerations
Excitotoxicity-mediated NO overproduction in neurological disorders
Beyond the preview
Go deeper on Nitric oxide synthase 1 (NOS1).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Nitric oxide synthase 1 (NOS1).