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Target intelligence / Profile preview
Nitric Oxide Synthase 2 (NOS2)
- Target
- NOS2
- Molecular classification
- Enzyme
01
Overview
Nitric oxide synthase 2 (NOS2), also known as inducible nitric oxide synthase (iNOS), is an enzyme that catalyzes the production of nitric oxide (NO) from L-arginine. It is induced in response to inflammatory stimuli and plays a critical role in antimicrobial defense and immune responses. While important for host defense, its dysregulation can contribute to inflammatory diseases and has a complex role in cancer.
- Other names
- iNOSInducible nitric oxide synthase
02
Mechanism of action
Inhibition of NO production via L-arginine binding site.
03
Biological functions
Nitric oxide productionAntimicrobial defenseAntitumoral activitiesModulation of vascular toneImmune responseNeurotransmission
04
Disease associations
InfectionInflammatory diseasesCancerImmunodeficiency
05
Safety considerations
Overexpression or dysregulation may contribute to inflammatory diseases due to excessive NO production.Dual role in cancer (tumor suppression vs. angiogenesis promotion).
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