Nitric oxide synthase 2A pseudogene

The nitric oxide synthase 2A pseudogene (ENSG00000225448) is a genomic DNA sequence that resembles the inducible nitric oxide synthase 2A (NOS2A) gene, but it is classified as a pseudogene, meaning it does not encode a functional enzyme or protein. Pseudogenes lack the necessary regulatory elements or contain deleterious mutations preventing normal transcription or translation, and thus do not yield an active protein product. While some pseudogenes may have regulatory RNA functions, such as acting as natural antisense transcripts or competing endogenous RNAs, there is no evidence that this pseudogene acts as a therapeutic target, nor is it included in standard drug or biomarker pipelines[5][7][9]. Important context: - The active, inducible form relevant to nitric oxide production, immune response, and certain disease mechanisms is the *NOS2* gene, not the pseudogene[1][2][3][4]. - Pseudogenes are often annotated in genomic studies but are not considered classical drug or therapeutic targets[9][5]. - Literature sometimes discusses regulatory effects of pseudogenes on their parental genes through RNA interference or miRNA decoy roles, but these mechanisms are highly context-dependent and not typically exploited clinically for this specific pseudogene[5][7][9]. This entry should not be treated as a genuine therapeutic target. For active research or drug development purposes, refer to the true gene, *Nitric oxide synthase 2 (NOS2, iNOS)*, which is a bona fide enzyme and therapeutic target in some settings[1][2][3][4].

Other names

NOS2A pseudogeneNOS2 pseudogenenitric oxide synthase pseudogene