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Target intelligence / Profile preview
Endothelial nitric oxide synthase (eNOS)
- Target
- eNOS
- Molecular classification
- Enzyme, Oxidoreductase
01
Overview
Endothelial nitric oxide synthase (eNOS) is a constitutively expressed enzyme crucial for cardiovascular health through its generation of nitric oxide—a molecule essential for regulating vessel tone, inhibiting thrombosis/inflammation within vessels—and whose dysfunction underlies many common cardiovascular pathologies. eNOS catalyzes the oxidation of L-arginine to produce nitric oxide (NO) and L-citrulline, requiring cofactors such as calmodulin, BH4, FMN, FAD, and NADPH.
- Other names
- NOS3cNOSNitric oxide synthase 3
02
Mechanism of action
Catalyzes the production of nitric oxide (NO) from L-arginine, leading to vasodilation and inhibition of platelet aggregation.
03
Biological functions
VasodilationRegulation of vascular toneInhibition of platelet aggregationAnti-inflammationNitric oxide synthesis
04
Disease associations
HypertensionAtherosclerosisDiabetes mellitusHeart failureSmoking-related damageCardiovascular disease
05
Safety considerations
eNOS uncoupling leading to superoxide productionPeroxynitrite formationReduced NO bioavailability
06
Interacting drugs
L-arginine
2 more in the full profile.
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