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Target intelligence / Profile preview
Nitric oxide synthase 3 endothelial cell type (eNOS)
- Target
- eNOS
- Molecular classification
- Enzyme, Nitric oxide synthase
01
Overview
Nitric oxide synthase 3 (NOS3), also known as endothelial nitric oxide synthase (eNOS), is an enzyme primarily responsible for generating nitric oxide (NO) in vascular endothelial cells. NO produced by eNOS plays a crucial role in regulating vascular tone, inhibiting platelet aggregation, controlling cellular proliferation, and modulating leukocyte adhesion—functions essential for cardiovascular health. Deficiency or dysfunction leads to impaired vasodilation and contributes to hypertension.
- Other names
- NOS3Endothelial nitric oxide synthasecNOSEC-NOS
02
Mechanism of action
Catalyzes the production of nitric oxide from L-arginine, leading to vasodilation and other downstream effects.
03
Biological functions
VasodilationRegulation of blood pressureInhibition of platelet aggregationRegulation of leukocyte adhesionNitric oxide production
04
Disease associations
Cardiovascular diseaseHypertensionEndothelial dysfunctionPulmonary hypertension
05
Safety considerations
eNOS uncoupling can lead to superoxide production and oxidative stress.Polymorphisms can affect enzyme activity and disease risk.
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