Nitric oxide synthase 3 pseudogene

Nitric oxide synthase 3 pseudogene refers to a genomic DNA sequence related to the protein-coding *NOS3* gene, but it is a **pseudogene**—meaning it does not produce a functional protein due to disabling mutations or sequence changes[4][5]. While canonical *NOS3* (endothelial nitric oxide synthase, eNOS) is an enzyme involved in nitric oxide production in vascular endothelium and has significant roles in vascular function and disease[2][6][11], its pseudogene counterpart does not encode an active enzyme or receptor. Pseudogenes can sometimes have regulatory roles, potentially affecting the expression of their parental genes via antisense RNA or other transcript-based mechanisms, but these roles are often species- and locus-specific and are less well characterized in humans relative to model organisms[1][4][5][9]. The entry ENSG00000266771 is not a therapeutic target and is unlikely to have known drug interactions, established biomarker value, or relevance in patient selection or drug safety. Additional Context and Clarification: The *NOS3* gene (protein-coding, not this pseudogene) is a well-established therapeutic target and encodes eNOS, which is involved in cardiovascular physiology and related diseases[3][6][10][11]. The **pseudogene** (ENSG00000266771) should not be confused with the protein-coding NOS3 gene (ENSG00000164867)[2]. Some pseudogenes of the nitric oxide synthase family in other species have been shown to regulate parental gene expression via antisense transcripts[1][4][9], but there is no evidence that this human pseudogene is itself a target for drugs, a biomarker, or directly implicated in any therapeutic context. This entry is considered "incorrect" as a drug target (is_incorrect: true) because: - It is a pseudogene, not a functional gene/protein. - There is no evidence it encodes an active target molecule (e.g., receptor, enzyme, transporter) relevant for drug action. - There are no known drugs, mechanisms, or safety concerns associated specifically with this pseudogene. If you are seeking information on the canonical target: - The correct entry is "Nitric oxide synthase 3 (eNOS/NOS3)", which is a well-characterized enzyme target in cardiovascular biology[2][3][6][11].

Other names

NOS3 pseudogenenitric oxide synthase pseudogene