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Target intelligence / Profile preview
Nitric oxide synthase inducible (iNOS)
- Target
- iNOS
- Molecular classification
- Enzyme, Paired donor oxygen oxidoreductase
01
Overview
iNOS (nitric oxide synthase inducible) is an enzyme responsible for the production of large amounts of nitric oxide (NO), primarily as part of the immune response. It is induced by cytokines and inflammatory stimuli in various cell types, including macrophages, and plays a crucial role in tumoricidal and bactericidal actions. Dysregulation of iNOS activity is associated with several diseases, including osteoarthritis, sepsis, cancer, and chronic kidney disease. It also has nitrosylase activity, mediating cysteine S-nitrosylation.
- Other names
- NOS2Peptidyl-cysteine S-nitrosylase NOS2NOS2ANOS type IIInducible NO synthaseHepatocyte NOS (HEP-NOS)
02
Mechanism of action
Inhibition of nitric oxide production
03
Biological functions
Immune responseNitric oxide productionProtein nitrosylationRegulation of vascular tone
04
Disease associations
OsteoarthritisSepsisSolid tumors/cancerChronic kidney diseaseInflammation
05
Safety considerations
Potential for immunosuppressionRisk of tissue damage due to dysregulated NO production
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