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Nitric oxide synthase inducible isoform (iNOS)
- Target
- iNOS
- Molecular classification
- Enzyme, Oxidoreductase
01
Overview
iNOS is a homodimeric enzyme that catalyzes the production of nitric oxide (NO) from L-arginine. It is induced by inflammatory cytokines and microbial products and plays a key role in immune defense and inflammation. Overexpression of iNOS is implicated in various diseases, making it a therapeutic target for modulating inflammatory responses and oxidative stress.
- Other names
- Peptidyl-cysteine S-nitrosylase NOS2NOS2ANOS type IIInducible NO synthaseHepatocyte NOS (HEP-NOS)
02
Mechanism of action
Inhibition of iNOS activity.
03
Biological functions
Nitric oxide synthesisImmune responseInflammationVasodilationS-nitrosylation
04
Disease associations
OsteoarthritisSepsisCancerChronic kidney diseaseInflammationNeurodegenerative diseaseCardiovascular disease
05
Safety considerations
Potential for immunosuppressionIncreased risk of infectionCardiovascular complicationsTissue damage from excessive NO production
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