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Nitric oxide synthase type I (nNOS)
- Target
- nNOS
- Molecular classification
- Enzyme
01
Overview
Nitric oxide synthase type I/nNOS catalyzes NO production from L‑arginine using multiple cofactors through a dimeric structure requiring calcium/calmodulin for activation. It plays essential roles primarily within neural tissues but impacts broader physiological processes including blood flow regulation and immune modulation. Dysfunctional nNOS activity contributes to several disease states via altered NO signaling pathways.
- Other names
- NOS1Neuronal nitric oxide synthase
02
Mechanism of action
Inhibition of nitric oxide production
03
Biological functions
Signal transductionNeurotransmission/modulationVascular regulationRegulation of smooth muscle relaxation
04
Disease associations
Neurodegenerative diseaseCardiovascular diseaseDiabetesInflammation
05
Safety considerations
Dysregulated vascular tone controlOxidative stress
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