Target intelligence / Profile preview

Nitric Oxide Synthase Type II (iNOS)

Target: iNOS
Molecular classification: Enzyme, Oxidoreductase

Overview

Nitric oxide synthase type II/iNOS/NOS2 is an inducible enzyme critical for host defense through robust production of antimicrobial nitric oxide during inflammation or infection—distinct from constitutive forms involved primarily in vascular regulation or neurotransmission.

Other names: iNOSNOS2Nitric oxide synthase 2Inducible nitric oxide synthase

Mechanism of action

Inhibition of nitric oxide production

Biological functions

Immune responseNitric oxide productionCytotoxicity

Disease associations

InfectionInflammationImmunodeficiency

Safety considerations

Potential for immunosuppressionOver-inhibition may impair host defenseNO overproduction can lead to inflammation and tissue damage

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