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Target intelligence / Profile preview
Nitroxyl (HNO)
- Target
- HNO
- Molecular classification
- Small Molecule, Reactive Nitrogen Species, Antioxidant, Neuroprotective Agent
01
Overview
Nitroxyl (HNO) is a simple triatomic molecule exhibiting unique pharmacological properties distinct from nitric oxide. It is a short-lived intermediate in solution due to its high reactivity and instability under physiological conditions. HNO acts as an antioxidant and neuroprotective agent, showing therapeutic potential in treating heart failure and mitigating ischemia-reperfusion injury. It reacts rapidly with thiols, making thiol-containing proteins primary targets within cells.
- Other names
- AzanoneNitrosyl hydrideOxidanimineNitroxide radicalOxyamine
02
Mechanism of action
Vasorelaxation; antioxidant activity by reacting with thiols and other reductants; neuroprotection by minimizing excitatory amino acid-induced injury.
03
Biological functions
VasorelaxationAntioxidant activityNeuroprotectionThiol oxidation
04
Disease associations
Heart failureIschemia-reperfusion injuryNeurodegenerative diseases
05
Safety considerations
High reactivity towards biological nucleophiles like thiolsLimited acute toxicity data, requires cautious handlingInstability in aqueous environments
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