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Target intelligence / Profile preview
NK Cell Lectin-like Receptor Subfamily C Member 1 (NKG2A)
- Target
- NKG2A
- Molecular classification
- Receptor, C-type lectin receptor, Type II transmembrane protein
01
Overview
NKG2A is an inhibitory receptor primarily expressed on NK cells and some T cell subsets. It forms a heterodimer with CD94 and recognizes HLA-E on target cells, delivering inhibitory signals that suppress immune responses. Its blockade is being explored as an immuno-oncology strategy.
- Other names
- CD159aNKG2NKG2-AKLRC1
02
Mechanism of action
Blocks the interaction of NKG2A with HLA-E, preventing inhibitory signaling and enhancing NK cell and T cell cytotoxicity.
03
Biological functions
Immune checkpointInhibition of NK cell activityInhibition of T cell activityRegulation of cytotoxicityRegulation of cytokine productionMaintenance of self-tolerance
04
Disease associations
CancerViral infectionsAutoimmunityInflammationTransplant rejection
05
Safety considerations
Potential for immune-related adverse events (irAEs)Exacerbation of autoimmune diseases
06
Interacting drugs
Monalizumab (IPH2201)
07
Biomarkers
HLA-E expression levels in tumorsNKG2A expression levels on immune cells
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