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Target intelligence / Profile preview
NK cell lectin-like receptor subfamily C member 1 (NKG2A) (NKG2A)
- Target
- NKG2A
- Molecular classification
- C-type lectin-like receptor, Inhibitory receptor, Type II transmembrane protein, Heterodimeric receptor
01
Overview
- Other names
- CD159aKLRC1NKG2-ANK cell receptor ANatural killer group 2 member A
02
Mechanism of action
Immune checkpoint inhibition by blocking the interaction between the NKG2A/CD94 heterodimer and its ligand HLA-E, thereby preventing inhibitory signaling and restoring the cytotoxic activity of NK cells and CD8+ T cells.
03
Biological functions
Immune responseSignal transductionInhibitory signalingNK cell regulationCD8+ T cell regulationSelf-tolerance
04
Disease associations
CancerHead and neck squamous cell carcinomaColorectal cancerNon-small cell lung cancerMultiple myelomaLeukemiaViral infectionAutoimmune diseaseInflammatory disease
05
Safety considerations
Immune-related adverse events (irAEs)Potential for autoimmunityCytokine release (when used in combination therapies)
06
Interacting drugs
Monalizumab (IPH2201)
07
Biomarkers
HLA-E expressionNKG2A expression on tumor-infiltrating lymphocytesHLA-G levelsNKG2A/NKG2C ratio
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