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NK Cell Lectin-Like Receptor Subfamily K
- Molecular classification
- Receptor, Type II transmembrane protein, Lectin-like receptor
01
Overview
NK cell lectin-like receptor subfamily K refers to a group of activating receptors primarily found on natural killer (NK) cells. The most well-characterized member in humans is encoded by the KLRK1 gene, which produces the NKG2D protein. These receptors play a crucial role in regulating immune responses against infections and neoplasms by recognizing stress-induced ligands like MICA/B and ULBPs.
- Other names
- Killer cell lectin-like receptor subfamily KNKG2DKLRK1
02
Mechanism of action
N/A
03
Biological functions
Immune responsePositive regulation of NK cell-mediated cytotoxicityTumor surveillanceAnti-infection immunitySignal transduction
04
Disease associations
CancerInfectious diseasesAutoimmune diseases
05
Safety considerations
Potential for off-target effects due to broad expression on immune cellsRisk of immune-related adverse events
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