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NKG2-C receptor (NKG2C)
- Target
- NKG2C
- Molecular classification
- C-type lectin-like receptor, Natural killer cell receptor
01
Overview
NKG2-C (also known as NKG2C) is an activating receptor expressed on human natural killer (NK) cells, belonging to the NKG2 family (CD159) within the C-type lectin-like receptor superfamily. It forms a heterodimer with CD94 and associates with the adaptor protein DAP-12 through a positively charged residue in its transmembrane region, lacking ITIMs but enabling ITAM-based signaling that promotes NK cell cytotoxicity, degranulation, and cytokine production upon binding HLA-E ligands. Unlike inhibitory NKG2A/B, NKG2-C activates NK cells, contributing to immune surveillance against tumors and infected cells, with higher expression in adaptive NK cells relevant to graft-versus-tumor effects.
- Other names
- NKG2CCD159cKLRC2
02
Biological functions
Positive regulation of natural killer cell mediated cytotoxicitySignal transduction via DAP-12 adaptorNK cell activation
03
Disease associations
CancerViral infectionImmune response modulation
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