Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
NKG2-D type II integral membrane protein (NKG2D)
- Target
- NKG2D
- Molecular classification
- C-type lectin-like receptor, Type II transmembrane protein, Receptor, CD94/NKG2 family
01
Overview
NKG2D is a type II transmembrane glycoprotein that functions as an activating and costimulatory receptor in the immune system. It is primarily expressed on natural killer (NK) cells, but also found on subsets of T cells. It recognizes stress-induced self-proteins that are structurally related to MHC class I molecules, playing a key role in immunosurveillance against tumors and virus-infected or stressed/damaged self-cells. The NKG2D-ligand axis is implicated in cancer immunosurveillance, and NKG2D pathway modulation has therapeutic potential, especially in cancer immunotherapy.
- Other names
- KLRK1Natural killer group 2 member DCD314
02
Mechanism of action
N/A
03
Biological functions
Immune responseCytotoxicityCostimulationImmunosurveillance
04
Disease associations
CancerViral infectionAutoimmunity
05
Safety considerations
Aberrant activation may contribute to autoimmunityTumor-mediated immune evasion via downregulation/shedding of ligands
06
Biomarkers
MICAMICBULBP1ULBP2ULBP3ULBP4RAET1/ULBP family members
Beyond the preview
Go deeper on NKG2-D type II integral membrane protein (NKG2D).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on NKG2-D type II integral membrane protein (NKG2D).