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NKX2-1 antisense RNA 1 (NKX2-1-AS1)
- Target
- NKX2-1-AS1
- Molecular classification
- Long non-coding RNA (lncRNA), Other
01
Overview
NKX2-1 antisense RNA 1 (NKX2-1-AS1) is a long non-coding RNA (lncRNA) located in chromosomal region 14q13.3, overlapping the protein-coding gene NKX2-1[1][7]. It does not encode a protein, but instead regulates gene expression independently of NKX2-1[1]. NKX2-1-AS1 is highly expressed in lung adenocarcinomas versus non-tumor or squamous cell controls[1]. Functionally, NKX2-1-AS1 modulates the expression of genes related to cell adhesion, migration, and immune checkpoints, notably negatively regulating CD274/PD-L1, thereby potentially influencing immune evasion in cancer[1]. It has also been implicated in promoting tumor progression and angiogenesis in gastric cancer, specifically via upregulation of SERPINE1 and activation of the VEGFR-2 pathway[6][7]. NKX2-1-AS1 may act as a microRNA sponge and is more stable than the NKX2-1 mRNA[4][1]. Although its biological roles are actively studied, it is not considered a canonical therapeutic target such as a receptor, enzyme, or transporter, and no drugs are known to specifically target NKX2-1-AS1 at present.
- Other names
- LOC105370453NKX2-1 antisense RNA 1 (non-protein coding)NKX2-1-AS1
02
Biological functions
Regulation of gene expressionRegulation of cell adhesion genesRegulation of migration of lung carcinoma cellsNegative regulation of PD-L1 (CD274) expressionAngiogenesis (in gastric cancer)Possible microRNA sponge function
03
Disease associations
Cancer (particularly lung adenocarcinoma, small cell carcinoma, and gastric cancer)Tumor progressionImmune evasion
04
Biomarkers
High expression in lung adenocarcinomaExpression pattern distinguishes adenocarcinoma from squamous carcinomaPotential marker for tumor migration and immune evasion
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