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NLGN4Y antisense RNA 1 (NLGN4Y-AS1)
- Target
- NLGN4Y-AS1
- Molecular classification
- Antisense long non-coding RNA (lncRNA), Non-coding RNA
01
Overview
NLGN4Y antisense RNA 1 (NLGN4Y-AS1) is an antisense long non-coding RNA found on the Y chromosome (chrY:14793642-14804033) that does not encode a protein and consists of 4 exons making up a 532 bp transcript. Like other antisense lncRNAs, it is thought to regulate expression of overlapping or neighboring genes through transcriptional interference or chromatin modifications, primarily acting in cis. Antisense RNAs can affect gene regulation at multiple levels (transcription, translation, chromatin architecture), and are important modulators in cell stress and development, though the specific functions and disease associations of NLGN4Y-AS1 remain largely uncharacterized in available databases and literature.
- Other names
- NLGN4Y-ASNLGN4YASNLGN4Y antisense RNA (non-protein coding)NLGN4Y antisense RNA 1 (non-protein coding)ENST00000434164.1NLGN4Y-AS1-001OTTHUMT00000130083.1NONHSAT139520NR_046504
02
Mechanism of action
Not applicable; no known drugs targeting NLGN4Y-AS1 Antisense RNAs generally act by base-pairing to sense mRNA, modulating splicing, translation, or stability, and causing transcriptional interference via chromatin remodeling or polymerase stalling
03
Biological functions
Regulation of gene expression (primarily in cis, sometimes trans)Modulation of chromatin structure and transcriptional interferencePutative involvement in speeding up gene expression during cell stress (mechanism inferred from antisense RNA family functions)
04
Disease associations
No specific roles in diseases documented in current literature for NLGN4Y-AS1 itselfGeneral: lncRNAs and antisense RNAs have emerging relevance in neurodevelopmental disorders, cancer, and imprinting disorders (based on broader antisense RNA research)
05
Safety considerations
None reported specific to NLGN4Y-AS1; targeting lncRNAs in general might have off-target and regulatory network risks
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