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Target intelligence / Profile preview
NLR family CARD domain containing 4 (NLRC4)
- Target
- NLRC4
- Molecular classification
- NLR family receptor, Inflammasome component, Pattern recognition receptor
01
Overview
NLRC4 is a key sensor of intracellular pathogens and a critical component of the NLRC4 inflammasome. Upon detection of specific bacterial or fungal ligands, NLRC4 oligomerizes and recruits caspase-1, leading to the maturation and secretion of pro-inflammatory cytokines IL-1β and IL-18. Mutations in NLRC4 are associated with autoinflammatory diseases. NLRC4 plays a role in both innate immunity and cell death.
- Other names
- CARD12Ipaf
02
Mechanism of action
NLRC4 inflammasome activation leads to caspase-1 activation and subsequent processing/release of pro-inflammatory cytokines.
03
Biological functions
Innate immunityInflammasome activationCaspase-1 activationCytokine processing (IL-1β, IL-18)Apoptosis
04
Disease associations
Autoinflammatory diseasesFamilial cold autoinflammatory syndrome (FCAS)CancerInfection
05
Safety considerations
Excessive inflammationPotential for cytokine stormOff-target effects on other inflammasomes
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