Target intelligence / Profile preview

NLR family CARD domain-containing protein 4 (NLRC4)

Target: NLRC4
Molecular classification: NOD-like receptor (NLR), Intracellular receptor

Overview

NLRC4 is a key component of the inflammasome, an innate immune sensor that responds to cytosolic bacterial infections. Upon activation by bacterial ligands via NAIP proteins, NLRC4 oligomerizes and recruits caspase-1, leading to the maturation of IL-1β and IL-18 and the induction of pyroptosis.

Other names: IPAF (ICE protease-activating factor)

Mechanism of action

NLRC4 inflammasome inhibitors are under development.

Biological functions

Inflammasome assemblyInnate immune responseCytokine maturationPyroptosis

Disease associations

Autoinflammatory diseasesInfection

Safety considerations

Excessive immunosuppression

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