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NLR Family Pyrin Domain Containing 1
- Molecular classification
- NLR family protein, Intracellular receptor
01
Overview
NLRP1 is an intracellular pattern recognition receptor that functions as a sensor of pathogens and cellular damage. Upon activation, NLRP1 assembles the inflammasome complex, leading to caspase-1 activation and subsequent maturation and secretion of the pro-inflammatory cytokines IL-1β and IL-18. It also plays a role in programmed cell death pathways including pyroptosis and apoptosis. Variants in NLRP1 are associated with autoimmune diseases such as Type I diabetes, lupus erythematosus, psoriasis, and vitiligo.
- Other names
- CARD7CLR17.1DEFCAPDKFZp586O1822KIAA0926NACNALP1SLEV1VAMAS1
02
Mechanism of action
NLRP1 inflammasome activation leads to caspase-1 activation, resulting in IL-1β and IL-18 maturation and secretion, and pyroptosis.
03
Biological functions
Inflammasome assemblyRegulation of inflammationRegulation of apoptosisCytokine productionInnate immunity
04
Disease associations
Type I DiabetesLupus ErythematosusPsoriasisVitiligoCrohn's DiseaseAutoimmune diseaseInflammation
05
Safety considerations
Potential for excessive inflammation if targeted improperlyAutoimmune complications
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