Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
NLR Family Pyrin Domain Containing 3 Inflammasome (NLRP3)
- Target
- NLRP3
- Molecular classification
- Pattern Recognition Receptor, Inflammasome, NLR family member
01
Overview
The NLRP3 inflammasome is a multiprotein complex crucial for the innate immune system. It senses both pathogen-associated and damage-associated molecular patterns, triggering inflammatory responses through caspase-1 activation and the maturation of pro-inflammatory cytokines like IL-1β and IL-18. Dysregulation of the NLRP3 inflammasome is implicated in various diseases, making it a therapeutic target for inflammation-driven conditions. The inhibitor MCC950 binds within the NACHT domain cavity distinct from nucleotide binding sites, stabilizing inactive conformations.
- Other names
- CIAS1CryopyrinPYPAF1NACHT-LRR-PYD-containing protein 3
02
Mechanism of action
Inhibition of NLRP3 inflammasome assembly and activation, stabilization of inactive conformations.
03
Biological functions
Innate immunityInflammationCaspase-1 activationCytokine maturation (IL-1β, IL-18)Pyroptosis
04
Disease associations
Cryopyrin-associated periodic syndromes (CAPS)GoutAtherosclerosisType 2 diabetesAlzheimer’s diseaseMultiple sclerosisAutoinflammatory disorders
05
Safety considerations
Potential for immunosuppressionOff-target effects due to broad inflammatory pathways
06
Interacting drugs
MCC950
Beyond the preview
Go deeper on NLR Family Pyrin Domain Containing 3 Inflammasome (NLRP3).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on NLR Family Pyrin Domain Containing 3 Inflammasome (NLRP3).