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Target intelligence / Profile preview
NLRP3 inflammasome activation (N/A)
- Target
- N/A
- Molecular classification
- Multiprotein complex, Inflammasome
01
Overview
NLRP3 inflammasome activation is a key event in the innate immune system, triggered by various stimuli including PAMPs, DAMPs, and cellular stress. This leads to the assembly of a multiprotein complex (NLRP3, ASC, Caspase-1) and the subsequent activation of caspase-1. Active caspase-1 cleaves pro-IL-1β and pro-IL-18 into their mature forms, leading to their secretion and promoting inflammation. Aberrant activation is linked to several diseases, making it a therapeutic target for inflammatory disorders.
- Other names
- NLR family pyrin domain containing 3 inflammasome activationNLRP3 inflammasome complex activation
02
Mechanism of action
Inhibition of NLRP3 inflammasome activation, leading to decreased caspase-1 activation and reduced IL-1β and IL-18 production.
03
Biological functions
Innate immune responseInflammationCaspase-1 activationIL-1β secretionIL-18 secretionPyroptosis
04
Disease associations
Cryopyrin-associated periodic syndromesAlzheimer’s diseaseDiabetes mellitusAtherosclerosisGoutNeurodegenerative diseasesInflammation
05
Safety considerations
Potential for immunosuppressionIncreased risk of infectionOff-target effects due to broad immune modulation
06
Biomarkers
IL-1β levelsIL-18 levelsCaspase-1 activity
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