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NMDA glutamate receptor (NMDAR)
- Target
- NMDAR
- Molecular classification
- Ionotropic glutamate receptor, Ligand-gated ion channel, Receptor
01
Overview
The NMDA glutamate receptor is an ionotropic glutamate receptor subtype that mediates excitatory neurotransmission in the central nervous system. It is a heterotetrameric complex typically composed of GluN1 and GluN2 (or GluN3) subunits. Activation requires the binding of glutamate and glycine (or D-serine) and the relief of Mg²⁺ block via membrane depolarization. It plays a crucial role in synaptic plasticity, learning, and memory, and is implicated in various neurological and psychiatric disorders due to its involvement in excitotoxicity.
- Other names
- NMDA receptorN-methyl-D-aspartate receptor
02
Mechanism of action
Ligand-gated ion channel activation; glutamate and glycine/D-serine binding, channel opening, ion flux (Ca²⁺, Na⁺, K⁺); voltage-dependent Mg²⁺ block relief.
03
Biological functions
Excitatory neurotransmissionSynaptic plasticityLearning and memoryNeuronal development
04
Disease associations
ExcitotoxicityIschemic strokeTraumatic brain injuryAlzheimer's diseaseEpilepsySchizophreniaMood disordersNeurodegenerative diseaseNeurological disordersPsychiatric conditions
05
Safety considerations
Excitotoxicity (excessive Ca²⁺ influx)Potential for neuronal injury/death with overactivation
06
Interacting drugs
APV/AP5
7 more in the full profile.
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