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Target intelligence / Profile preview
NMDA Receptor NR2B Subunit (GluN2B)
- Target
- GluN2B
- Molecular classification
- Ion channel, Receptor, Glutamate receptor, NMDA receptor
01
Overview
The NMDA receptor NR2B subunit (GluN2B) is a critical component of the NMDA receptor complex, an ionotropic glutamate receptor in the central nervous system. It plays a crucial role in synaptic plasticity, learning, memory, and pain perception. The receptor is a heterotetramer, typically composed of two NR1 subunits and two NR2 subunits. The NR2B subunit contributes unique biophysical and pharmacological properties to the receptor complex. Mutations or dysregulation of NR2B have been linked to various neurological disorders, including epilepsy, Alzheimer’s disease, stroke, Parkinson’s disease, and intellectual disability.
- Other names
- NMDAR2BGRIN2BNMDA receptor subunit epsilon‐twoepsilon(ε)-subunit
02
Mechanism of action
Agonist binding leading to calcium influx; allosteric modulation via zinc binding; antagonist binding blocking ion channel activity
03
Biological functions
Synaptic transmissionSynaptic plasticityLong-term potentiation (LTP)Long-term depression (LTD)Learning and memoryPain perceptionExcitatory neurotransmission
04
Disease associations
EpilepsyAlzheimer’s diseaseStrokeParkinson’s diseaseIntellectual disabilityChronic painNeuropathic painInflammatory pain syndromes
05
Safety considerations
Dysregulation linked to neurological disordersPotential for excitotoxicity
06
Interacting drugs
Glutamate
4 more in the full profile.
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