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Target intelligence / Profile preview
NMDA Receptor Subunit NR2A (GluN2A)
- Target
- GluN2A
- Molecular classification
- Ion channel, Ligand-gated ion channel, Glutamate receptor, NMDA receptor subunit
01
Overview
The NMDA receptor subunit NR2A (GluN2A) is a critical subunit of the NMDA receptor, an ionotropic glutamate receptor essential for synaptic plasticity, learning, memory, and neural development. NR2A-containing receptors contribute to faster deactivation kinetics and synapse stabilization compared to other NR2 subunits. Its developmental upregulation is crucial for the transition from highly plastic juvenile circuits to more stable adult networks.
- Other names
- NR2AGluN2ANMDAR2AGRIN2A
02
Mechanism of action
Agonist, antagonist, or modulator of NMDA receptor activity; modulation of ion channel conductance
03
Biological functions
Synaptic plasticityLearningMemoryNeural developmentSynapse stabilizationExcitatory neurotransmission
04
Disease associations
Neurodevelopmental disordersCognitive dysfunctionEpilepsySchizophreniaAutism Spectrum DisorderAlzheimer's disease
05
Safety considerations
ExcitotoxicityNeurodevelopmental effectsPsychomimetic effects (for some antagonists)Seizures
06
Interacting drugs
AP5
5 more in the full profile.
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